Publications

2017-2010    2009-2005     2004-2000     1999-1995     1994-1990     1989-1980

160. I.R.G Thistlethwaite, F.M. Bull, C. Cui, P.D. Walker, S-S. Gao, L. Wang, Z. Song, J. Masschelein, R. Lavigne, M.P. Crump, P.R. Race, T.J. Simpson., C.L. Willis, Chem. Sci., 2017, Advance Article. DOI: 10.1039/C7SC01670K

159. S-S. Gao, L. Wang, Z. Song, J. Hothersall, E.R. Stevens, J. Connolly, P.J. Winn, R.J. Cox, M. P. Crump, P.R. Race, C.M. Thomas, T.J. Simpson, C.L. Willis, Angew. Chem. Int. Ed., 2017, 56, 3930-3934. DOI :10.1002/anie.201611590

158. K. Williams, A.J. Szwalbe, C. Dickson, T.R. Desson, N.P. Mulholland, J.L. Vincent, J.M. Clough, A.M. Bailey, C.P. Butts, C.L. Willis, T.J. Simpson, R.J. Cox, Chem. Commun., 2017, 53, 7695-7968. DOI: 10.1039/C7CC03303F

157. E. Liddle, A. Scott, L.-C. Han, D. Ivison, T.J. Simpson, C. L. Willis, R. J. Cox, In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase, Chem. Commun., 2017, 53, 1727-1730, DOI: 10.1039/C6CC10172K

 156. M. J. Byrne, N. R. Lees, L.-C. Han, M. W. van der Kamp, A.J. Mulholland, J. E. M. Stach, C. L. Willis, P. R. Race, The catalytic mechanism of a natural Diels-Alderase revealed in molecular detail, J. Am. Chem. Soc., 2016, 138 (19), 6095-6098, DOI: 10.1021/jacs.6b00232.

155. K. Williams, A. J. Szwalbe, N. P. Mulholland, J. L. Vincent, A. M. Bailey, C .L. Willis,  T. J. Simpson  and R. J. CoxHeterologous production of fungal maleidrides reveals the cryptic cyclization involved in their biosynthesis, Angew Chem. Int. Ed., 2016, 55, 6784-6788, DOI: 10.1002/anie.201511882 

154. A. M. Bailey, F. Alberti, S. Kilaru, C. M. Collins, K. deMattos-Shipley, A.J. Hartley, P. Hayes, A. Griffin, C. M. Lazarus, R. J. Cox, C. L. Willis, K. O’Dwyer, D. W. Spence, G. D. Foster, Identification and Manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production, Scientific Reports 2016, 6, 25202

153. R. J. Beattie, T. W. Hornsby, G. Craig, M. C. Galan and C. L. Willis, Stereoselective Synthesis of Protected L- and D-Dideoxysugars and Analogues via Prins Cyclisations, Chem. Sci., 2016, 7, 2743-2747

152. X. Dong, C. D. Bailey, C. Williams, T. J. Simpson, J. Crosby, C. L. Willis and M. P. Crump, Recognition of extended linear and cyclised polyketide mimics by a Type II acyl carrier protein, Chem. Sci., 2016, 7, 1779-1785

151. A. J. Szwalbe, K. Williams, D. E. O’Flynn, A. M. Bailey, N. P. Mulholland, J. L. Vincent, C. L. Willis, R. J. Cox, T. J. Simpson, Chem. Commun., 2015, 51, 17088-17091.

150. T. D. Ackrill, H. A. Sparkes and C. L. Willis, Synthesis of diarylheptanoid scaffolds inspired by calyxins I and J, Org. Lett., 2015, 17, 3884-3887.

149. D. K. Shoemark, C. Williams, M. S. Fahey, J. J Watson, S. J. Tyler, S. J. Scoltock, R. Z. Ellis, E. Wickenden, A. J. Burton, J. L. Hemmings, C. D. Bailey, D. Dawbarn, D. E. Jane, C. L. Willis, R. B. Sessions, S. J. Allen and M. P. Crump, Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobin tyrosine kinase A (TrkAlg2) domain construct for binding site elucidation in drug discovery, J. Med. Chem., 2015, 58, 767-777.

148. S. Gao, J. Hothersall, J. Wu, A. C. Murphy, Z. Song, E. R. Stephens, C. M. Thomas, M. P. Crump, R. J. Cox,  T. J. Simpson and C. L. Willis,  Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways, J. Am. Chem. Soc, 2014, 136, 5501-5507.

147. M. J. Hesse, S. Essafi, C. G Watson, J. N. Harvey, D. Hirst, C. L. Willis and V. K. Aggarwal, Highly Selective Allylborations of Aldehydes using α,α-Disubstituted Allylic Pinacol Boronic Esters, Angew. Chem. Int. Ed., 2014, 53, 6145-6149.

146. A. C. Murphy, S. Gao,  L.-C. Han,  J. Hothersall, S.  Carobene,  D. Fukuda,Z.  Song,  R. J. Cox, J.  Crosby, M. P. Crump, C. M. Thomas, C. L. Willis and T. J. Simpson, Biosynthesis of Thiomarinol A and Related Metabolites of Pseudoalteromonas sp. SANK 73390, Chemical Science, 2014, 5, 397-402.

145. B.D. Cons, A.J. Bunt, C. D. Bailey and C. L. Willis, Total synthesis of (-)-blepharocalyxin D and analogues, Org Lett., 2013, 15, 2046-2049.

144. A. Phanumartwiwath, T. W. Hornsby, J. Jamalis, C. D. Bailey and C. L. Willis, Silyl Migrations in D-Xylose Derivatives: Total Synthesis of a Marine Quinoline Alkaloid, Org. Lett., 2013, 15, 5734-5737. 

143. J. L.-Y. Chen, H. K. Scott, M. J. Hesse, C. L. Willis, and V. K. Aggarwal,* Highly Diastereo- and Enantioselective Allylboration of Aldehydes using α-Substituted Allyl/Crotyl Pinacol Boronic Esters via in Situ Generated Borinic Ester, J. Am. Chem. Soc., 2013, 135, 5316–5319.

142.  A. S. Haines, X. Dong, Z.Song, R. Farmer, C. Williams, J. Hothersall, E. Płoskoń, P. Wattana-amorn, E. R. Stephens, E. Yamada, R. Gurney, Y. Takebayashi, J. Masschelein, R. J. Cox, R. Lavigne, C. L. Willis, T. J. Simpson, J. Crosby, P. J. Winn, C. M. Thomas and M. P. Crump, A conserved motif flags acyl carrier proteins for b-branching in polyketide synthesis, Nat. Chem. Biol, 2013, 9, 685-692.

141. M. J. Hesse, C. P. Butts, C. L. Willis and V. K. Aggarwal, Diastereo-divergent synthesis of trisubstituted alkenes through protodeboronation of allylic boronic esters; Application to the synthesis of the Californian red scale beetle pheromone, Angew Chem. Int. Ed., 2012, 51, 12444-12448.

140. J.C. Killen, L.C. Axford, S.E. Newberry, T.J. Simpson and C. L. Willis, Convergent syntheses of 3,6-dihydroxydec-4-enolides, Org. Lett., 2012, 14, 4194-4197.

139. A.J. Bunt, C. D. Bailey, B.D. Cons, S.J. Edwards, J. D. Elsworth, T. Pheko and C. L. Willis, Bicyclic oxygen heterocycles from α,β-unsaturated alcohols: Synthetic targets inspired by blepharocalyxin D, Angew. Chem. Int. Ed., 2012, 51, 3901-3904.

138. R. W. Scott, C. Mazzetti, N. Saunders, T. J. Simpson and C. L. Willis γ-Lactones from δ-lactones: Total synthesis of the pseudomonic acid biosynthetic derailment product mupirocin H, Chem Commun, 2012, 48, 2639-2641.

137. R. W. Scott, A. C. Murphy, J. Wu, J. Hothersall, R. J. Cox, T. J. Simpson, C. M. Thomas and C. L. Willis Mupirocin F: Structure elucidation, synthesis and rearrangements, Tetrahedron, 2011, 67, 5098-5106. invited article.

136. D. Fukuda, A.S. Haines, Z. Song, A.C. Murphy, J. Hothersall, E.R. Stephens, R. Gurney, R.J. Cox, J. Crosby, C.L. Willis, T.J. Simpson and C.M. Thomas, A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA hybrid, PLOS ONE, 2011, 6 (issue 3), e18031.

135. J. Hothersall, A. C. Murphy, Z. Iqbal, G. Campbell, E. R. Stephens, J. Wu, H. Cooper, S. Atkinson, P. Williams, J. Crosby, C. L. Willis, R. J. Cox, T. J. Simpson and C. M. Thomas,“Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production”, Appl. Microbiol. and Biotechnol., 2011, 90, 1017-102.

134. A. C. Murphy, D. Fukuda, Z. Song, J. Hothersall, R. J. Cox, C. L. Willis, C. M. Thomas and T. J. Simpson, Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of Pseudomonas SANK73390, Angew. Chem. Int. Ed., 2011, 50, 3271-3274.

133. S. Tapaneeyakorn, A.D. Goddard, J. Oates, C. L. Willis and A. Watts, Solution- and solid-state NMR studies of GPCRs and their ligands, Biochim. Biophys. Acta-Biomembranes, 2011, 1808, 1462-1475.

132. E. Owusu-Ansah, A.C. Durow, J.R. Harding, A.C. Jordan, S.J. O’Connell and C.L. Willis, Synthesis of dysideaproline E using organocatalysis, Org. Biomol. Chem., 2011, 9, 265- 272.

131. E. Ploskon, C. J. Arthur, A. P. Kanari, P. Wattana-amorn, C. Williams, J. Crosby, T. J. Simpson, C. L. Willis and M. P. Crump, Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis, Chem. Biol., 2010, 17, 776-785.

130. S. R. Crosby, R. B. Sessions and C. L. Willis, Intermediate for the synthesis of 4-substituted proline derivatives, Synlett., 2010, 539-542. (Invited article to celebrate the 70th birthday of Professor Gerry Pattenden)

129. R.W. Alder, F. Carta, C. A. Reid, I. Stoyanova and C.L. Willis, Searching for intermediates in Prins cyclisations: the 2-oxa-5-adamantyl carbocation, Org. Biomol. Chem., 2010, 8, 1551-1559.

128. Invited Review Article: C.M. Thomas, J. Hothersall, C.L. Willis and T.J. Simpson, Resistance to and synthesis of the antibiotic mupirocin, Nature Reviews Microbiology, 2010, 8, 281-289.

127. C. Song, S. Tapaneeyakorn, A. Murphy, C. Butts, A. Watts, and C. L. Willis, Enantioselective synthesis of α-Fmoc Pbf-[13C]-L-arginine and Fmoc-[1,3-13C2]-L-proline and incorporation into the neurotensin receptor ligand, NT 8-13, J. Org. Chem,, 2009, 74, 8980-8987.

126. A.C. Durow, C. Butts and C.L. Willis, Stereochemical assignment of the chlorinated residues in victorin C, Synthesis, 2009, 17, 2954-2762.

125. S. E. Evans, C. Williams, C.J. Arthur, E. Ploskoń, P. Wattana-amorn, R.J. Cox, J. Crosby, C.L. Willis, T.J. Simpson and M.P. Crump, Probing the interactions of early polyketide intermediates with the actinorhodin ACP from S. coelicolor A3 (2), J. Mol. Biol., 2009, 389, 511-528.

124. P. T. Seden and C. L. Willis, “Synthesis of a Novel Diarylheptanoid Isolated from Zingiber officinale”, Tetrahedron Lett., 2009, 50, 3686-3689. Invited article to celebrate the 50th anniversary of Tetrahedron Letters.

123. Invited Review Article: M. Strickland and C.L. Willis. “Synthesis of halogenated amino acids, in “Amino Acids, Peptides and Proteins in Organic Chemistry”, Wiley VCH, Ed A. B. Hughes, 2009, Chapter 11, 441-471.

122. T.J. Simpson, F. Soulas and C.L. Willis, A Cautionary Tale in Decanolide Synthesis, Synlett., 2008, 14, 2196-2198. (Invited article to celebrate the 70th birthday of Professor Sir Jack Baldwin)

121. J. Wu, J. Hothersall, C. Mazzetti, Y.O’Connell, J.A. Shields, R.J. Cox, J. Crosby, T.J. Simpson, C.M. Thomas and C.L. Willis. In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the “leaky hosepipe” mechanism, ChemBioChem, 2008, 9, 1500-1508.

120. P. T. Seden, J. P. H. Charmant and C. L. Willis. Total synthesis of the marine metabolite clavosolide D, Org. Lett., 2008, 10, 1637-1640.

119. J. D. Elsworth and C. L. Willis. Intramolecular Prins cyclisations for the stereoselective synthesis of bicyclic tetrahydropyrans, Chem. Comm., 2008, 1587-1589.

118. J. Hothersall, J. Wu, A.S. Rahman, J.A. Shields, J. Haddock, N. Johnson, S.M. Cooper, E.R. Stephens, R.J. Cox, J. Crosby, C.L. Willis, T.J. Simpson and C.M. Thomas, Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A., J. Biol. Chem, 2007, 282, 15451-15461.

117. J. Wu, S.M. Cooper, R.J. Cox., J. Crosby, J. Hothersall, T.J. Simpson, C.M. Thomas and C.L. Willis, Mupirocin H, a novel metabolite isolated from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens, Chem Comm., 2007, 2040-2042.

116. D.O. Rees, N. Bushby, J.R. Harding, C. Song and C.L. Willis, Synthesis of isotopically labeled amino acids, J. Label. Compd. Radiopharm., 2007, 50, 399-401.

115. A. Jordan, L.C. Axford, J.R. Harding, Y. O’Connell, T.J. Simpson and C.L. Willis, Methods for the synthesis of carbon-13 labelled acids and esters, J. Label. Compd. Radiopharm., 2007, 50, 338-341.

114. D.O. Rees, N. Bushby, R.J. Cox, J.R. Harding, T.J. Simpson and C.L. Willis, Synthesis of [1,2-13C2,15N]-L-homoserine and incorporation by the PKS-NRPS system of Fusarium moniliforme into the mycotoxin fusarin C, ChemBioChem., 2007, 8, 46-50.

113. A.C. Durow, G.C. Long, S.J. O’Connell and C.L. Willis, Total synthesis of the marine natural product dysamide B, Org. Lett., 2006, 8, 5401-5404.

112. D. Dawbarn, M. Fahey, J. Watson, S. Tyler, D. Shoemark, R. Zhang, L. Brady, C. Willis and S. J. Allen, NGF receptor TrkAd5: therapeutic agent and drug design target, Biochem. Soc. Trans., 2006, 34, 587-590.

111. C.S. Barry, J.D. Elsworth, P.T. Seden, N. Bushby, J.R. Harding, R.W. Alder and C.L. Willis, “Total synthesis of the marine natural product (-)-clavosolide A”, Org. Lett, 2006, 8, 3319-3322.

110. P.M. Flatt, S.J. O’Connell, K.L. McPhail, G. Zeller, C.L. Willis, D.H. Sherman and W.H. Gerwick, Characterization of the initial enzymatic steps of barbamide biosynthesis, J. Nat.Prod., 2006, 69, 938-944.

109. C.S. Barry, N. Bushby, J.P.H. Charmant, J.D. Elsworth, J.R. Harding and C.L. Willis, Total synthesis of a diastereomer of the marine natural product clavosolide A. Chem. Comm.,2005, 5097-5099.

108. C.S. Barry, N. Bushby, J.R. Harding, R.A. Hughes, G.D. Parker, R. Roe and C.L. Willis, Probing the mechanism of Prins cyclisations and application to the synthesis of 4-hydroxytetrahydropyrans. Chem. Comm., 2005, 3727-3729.

107. C.S. Barry, N. Bushby, J.R. Harding and C.L. Willis, Stereoselective synthesis of the tetrahydropyran core of polycavernoside A. Org. Lett., 2005, 7, 2683-2686.

106. C. Le Sann, D.M. Muñoz, N. Saunders, T.J. Simpson, D.I. Smith, F. Soulas, P. Watts and C.L. Willis, Assembly intermediates in polyketide biosynthesis: Enantioselective syntheses of β-hydroxycarbonyl compounds, Org. Biomol. Chem., 2005, 3, 1719-1728.

105. C.L. Willis and M. Wills, “Syntheza Organiczna”, Oxford University Press, 2004, Polish Translation of Oxford University Primer, reference 52. C.L. Willis and M. Wills, “Sintesis Organik”, Oxford University Press, 2004, Indonesian Translation of Oxford University primer, reference 52.

104. D.M. Muñoz, S.C. Passey, T.J. Simpson, C.L. Willis, J.B. Campbell and R. Rosser, Two approaches to the synthesis of the macrodiolide colletotriene, Aust. J. Chem., 2004, 645-649.

103. C. St.J. Barry, J.R. Harding, C.D. King, G.D. Parker and C.L. Willis, “Stereocontrolled synthesis of oxygen containing heterocycles” in “Synthesis and Applications of Isotopes and Isotopically Labelled Compounds, Volume 8, Eds. D. Dean, C. Filer and K. McCarthy, Wiley, 2004, 137-140.

102. J.E. Clare, K.W.M. Lawrie, C.L. Willis and J. Yuen, “Synthesis of isotopically labelled nitrogen heterocycles” in Synthesis and Applications of Isotopes and Isotopically Labelled Compounds, Volume 8, Eds. D. Dean, C. Filer and K. McCarthy, Wiley, 2004, 1-4.

101. A.G. Jamieson, A. Sutherland and C.L. Willis, The first enantioselective synthesis of the amino acid, (2S,3S,4R)--hydroxyleucine using a palladium (II) catalysed 3,3-sigmatropic rearrangement. Org. Biomol. Chem., 2004, 808-809.

100. L.C. Axford, T.J. Simpson and C.L. Willis, Synthesis and incorporation of the first PKS-free intermediate in monocerin biosynthesis, Angew. Chem., Int. Ed, 2004, 727-730.

99. J.E. Clare, C.L. Willis, J. Yuen, K.W.M. Lawrie, J.P.H. Charmant and A. Kantcha, Intermediates in the synthesis of nitrogen heterocycles: Addition of acylated camphorsultams to nitroalkenes, Tetrahedron Lett., 2003, 44, 8153-8156.

98. C. St.J Barry, S. R. Crosby, J. R. Harding, R. A. Hughes, C. D. King, G. D. Parker and C. L. Willis, Stereoselective synthesis of 4-hydroxy-2,3,6-trisubstituted tetrahydropyrans. Org. Lett., 2003, 5, 2429-2432.

97. W.H. Gerwick, P. Leslie, G.C. Long, B.L. Marquez and C.L. Willis, [6-13C]-(2S,4S)-5-Chloroleucine: Synthesis and incubation studies with cultures of the cyanobacterium, Lynbya majuscula. Tetrahedron Lett., 2003, 44, 285-288.

96. S.R . Crosby, J.R Harding, C.L . King, G. D. Parker and C.L. Willis, Prins cyclisations: labeling studies and application to natural product synthesis. Org. Lett., 2002, 4, 3407-3410.

95. Z. Chang, P. Flatt, W.H. Gerwick, V.-A. Nguyen, C.L. Willis and D.H. Sherman, The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide (PKS)-non-ribosomal peptide synthase (NRPS) origin involving an unusual trichloromethyl starter unit. Gene, 2002, 296, 235-247.

94. S.R. Crosby, J.R. Harding, C.D. King, G.D. Parker and C.L. Willis, Oxonia-Cope rearrangement and side-chain exchange in the Prins cyclisation” Org. Lett.,, 2002, 4, 577-580.

93. J.L. Ward, P. Gaskin, R.G.S. Brown, G.S. Jackson, P. Hedden, A.L. Phillips, C.L. Willis and M.H. Beale, Probing the mechnism of loss of carbon-20 in gibberellin biosynthesis. Synthesis of gibberellin 3α,20-hemiacetal and 19,10-lactol analogues and their metabolism by recombinant GA 20-oxidase. J. Chem. Soc., Perkin Trans. 1, 2002, 232-241.

92. A.Q. Chen and C.L. Willis. Unexpected stereospecific rearrangement-addition reactions of trisubstituted gibbereliin epoxides with trimethylaluminium, Chinese Chem. Letts., 2001, 12, 855-858.

91. A.Q. Chen and C.L. Willis. Stereoselctive functionalization at C-2 and C-3 of the gibberellins via an intramolecular free-radcal cyclization approach, Chinese Chem. Letts., 2001, 12, 397-398.

90. V.-A. Nguyen, C.L. Willis and W.H. Gerwick, Total synthesis of the marine natural product barbamide. Chem. Commun, 2001, 1934-1935.

89. E.H. Al-Mutairi, S.R. Crosby, J. Darzi, J.R. Harding, R.A. Hughes, C.D. King, T.J. Simpson, R.W. Smith and C.L. Willis, Stereocontrolled synthesis of 2,4,5-trisubstituted tetrahydropyrans. Chem. Commun., 2001, 835-836.

88. J.A. O’Neill, T.J. Simpson and C.L. Willis, “Synthetic and biosynthetic studies on macrocyclic dilactones” in “Synthesis and Applications of Isotopes and Isotopically Labelled Compounds, vol 7”, Ed. U. Pleiss and R. Voges, Wiley, 2001, 636-639.

87. K.W.M. Lawrie, C.L. Kelly, P. Morgan and C.L. Willis, “Multicomponent condensations for the synthesis of isotopically labelled amino acids” in “Synthesis and Applications of Isotopes and Isotopically Labelled Compounds Vol 7”, Ed. U. Pleiss and R. Voges, Wiley, 2001, 291-294.

86. A. Sutherland and C.L. Willis, Synthesis of fluorinated amino acids. Nat. Prod. Reports, 2000, 17, 621-631.

85. N. Sitachitta, B.L. Marquez, R.T. Williamson, J. Rossi, M.A. Roberts, W.H. Gerwick, V-A. Nguyen and C.L. Willis, Barbamide and dechlorobarbamide, molliscicidal agents from the marine cyanobacterium, Lyngbya majuscula: Biosynthetic pathway and origin of the chlorinated methyl group, Tetrahedron, 2000, 56, 9103-9113.

84. C.L. Kelly, K.W.M. Lawrie, P. Morgan and C.L. Willis, Ugi four component condensations using aldehydes with an asymmetric centre at C-2. Tetrahedron Lett., 2000, 41, 8001-8005.

83. J.R. Harding, R.A. Hughes, N.M. Kelly, A. Sutherland and C.L. Willis, Syntheses of isotopically labelled L-amino acids with an asymmetric centre at C-3. J. Chem. Soc., Perkin Trans. 1, 2000, 3406-3416.

82. S. Clough, M.E. Raggatt, T.J. Simpson, C.L. Willis, A. Whiting and S.K. Wrigley, Structure elucidation and synthesis of (4S,5S,6Z,8E)-5-hydroxydeca-6,8-dien-4-olide (S,S, Sapinofuranone B) – a novel γ-lactone metabolite of Acremonium strictum. J. Chem. Soc., Perkin Trans. 1, 2000, 2475-2481.

81. C. Mckay, T.J. Simpson, C.L. Willis, A.K. Forrest and P.J. O’Hanlon, A versatile approach to the total synthesis of the pseudomonic acids. Chem. Commun., 2000, 1109-1110.

80. G. Bhalay, S. Clough, L. McLaren, A. Sutherland and C.L. Willis, Synthesis and enzyme-catalysed reductions of 2-oxo acids with oxygen containing side-chains. J. Chem. Soc., Perkin Trans. 1, 2000, 901-910.

79. S. R. Crosby, M. J. Hateley and C.L. Willis, Chemoenzymatic syntheses of cis- and trans-3-hydroxy-5-methylpiperidin-2-ones. Tetrahedron Letters, 2000, 41, 397-401.

78. M.D. Fletcher, J.R. Harding, R.A. Hughes, N.M. Kelly, H. Schmalz, A. Sutherland and C.L. Willis, Three approaches to the synthesis of L-leucine selectively labelled with carbon-13 or deuterium in either diastereotopic methyl group, J. Chem. Soc., Perkin Trans. 1, 2000, 43-52.

77. F. Ahmed, E. H. Al-Mutairi, K. L. Avery, P. M. Cullis, W. U. Primrose, G. C. K. Roberts and C. L. Willis, An unusual matrix of stereocomplementarity in the hydroxylation of monohydroxy fatty acids catalysed by cytochrome P450 from Bacillus megaterium with potential application in biotransformations. Chem. Commun., 1999, 2049-2050.

76. A. Sutherland and C. L. Willis, Probes for the active sites of leucine dehydrogenase. Bioorg. Med. Chem. Letts., 1999, 9, 1941-1944.

75. C. LeSann, T. J. Simpson, D. I. Smith, P. Watts and C. L. Willis, A general synthesis of homochiral β-hydroxy N-acetylcysteamine thioesters. Tetrahedron Lett., 1999, 40, 4093-4096.

74. G. Gibbs, M. J. Hateley, L. McLaren, M. Welham and C. L. Willis, Enantioselective synthesis of 3-hydroxypiperidin-2-ones. Tetrahedron Lett., 1999, 40, 1069-1072.

73. J. A. Macritchie, A. Silcock and C. L. Willis, Iodocyclisation studies on unsaturated -hydroxy esters. Tetrahedron Lett., 1998, 39, 7415-7418.

72. A. Sutherland and C. L. Willis, Chemoenzymatic synthesis of 4-amino-2-hydroxy acids: A comparison of mutant and wild-type oxidoreductases. J. Org. Chem., 1998, 63, 7764-7769.

71. N. Sitachitta, J. Rossi, M.A. Roberts, W.H. Gerwick, M.D. Fletcher and C.L. Willis, Biosynthesis of the marine cyanobacterial metabolite barbamide. 1. Origin of the trichloromethyl group, J. Am. Chem. Soc., 1998, 120, 7131-7132.

70. M.D. Fletcher, N.M. Kelly, A. Sutherland and C.L. Willis, “Enantioselective synthesis of L-α-amino acids incorporating stable isotopic labels”, in Synthesis and Applications of Isotopes and Isotopically Labelled Compounds 1997, Ed. J. R. Heys and D. G. Melillo, Wiley, 1998, p161-165.

69. J.A. Macritchie, A. Silcock and C.L. Willis, Enantioselective synthesis of unsaturated -hydroxy acids. Tetrahedron: Asymmetry, 1997, 8, 3895-3902.

68. C. Clissold, C. L. Kelly, K. W. M. Lawrie and C. L. Willis, Synthesis of tetrasubstituted -lactones, Tetrahedron Lett., 1997, 38, 8105-8108.

67. C.L. Willis and M. Wills, Syntheseplanung in der Organischen Chemie, 1997, VCH, Weinheim, German Translation of Oxford University Primer, reference 52.

66. M. Penny, S.M. Westaway and C.L. Willis, Displacement of bridgehead sulfonate esters with organometallic reagents: Synthesis of 13-alkylated gibberellins. J. Chem. Soc., Perkin Trans. 1, 1997, 2989-2995.

65. T.J. Simpson, R.W. Smith, S.M. Westaway, C.L. Willis, A.J. Buss, R. Carnell, M. Dawson and B.A. M. Rudd, Enantioselective synthesis of a putative hexaketide in squalestatin biosynthesis. Tetrahedron Lett., 1997, 38, 5367-5370.

64. A. Sutherland and C.L. Willis, Enantioselective synthesis of α-amino-β-hydroxy acids, [15N]-L- allothreonine and [15N]-L-threonine. Tetrahedron Lett., 1997, 38, 1837-1840.

63. J. L. Ward, G. J. Jackson, M. H. Beale, P. Gaskin, P. Hedden, L. N. Mander, A. L. Phillips, H. Seto, M. Talon, C. L. Willis, T. M. Wilson and J. A. D. Zeevaart, Stereochemistry of the oxidation of the gibberellin 20-alcohols, GA15 and GA44, to 20-aldehydes by gibberellin 20-oxidases. J. Chem. Soc., Chem. Commun., 1997, 13-14.

62. N. M. Kelly, A. Sutherland and C. L. Willis, Synthesis of amino acids incorporating stable isotopes. Nat. Prod. Reports, 1997, 14, 205-219.

61. M.H. Beale, H. Loaring, T. Peakman, M. Penny and C.L. Willis, Unusual reactions of methanesulfonyl esters: Syntheses of 3α- and 3β- methylgibberellin A20. J. Chem. Soc., Perkin Trans. 1, 1997, 433-442.

60. S. Findlow, P.A. Harrison, M. Penny, C.L. Willis, P.Gaskin and J.R. Lenton. Synthesis of gibberellins A93 and A94, natural products detected in wheat grain. J. Chem. Soc., Perkin Trans. 1, 1997, 751-757.

59. N. Bernard, J. Delcour, A. Alvarez, A. Cortes, K. Johnsen, C. L. Willis, C. R. Dunn, A. R. Clarke and J. J. Holbrook, Correction of substrate inhibition in dehydrogenases. 24th Meeting Federation of European Biochemical Societies, Barcelona, 1996, 79.

58. N. Bernard, J. Delcour, A. Alvarez, A. Cortes, C. L. Willis, C. R. Dunn and J. J. Holbrook, Engineering to correct substrate inhibition in a commercial dehydrogenase, 5th Perspectives on Protein Engineering Conference, Montpellier, 1996, 25.

57. T. J. Simpson and C. L. Willis, “Enzymatic and Chemical Methods for the Enantioselective Synthesis of Isotopically Labelled Amino Acids and Metabolic Intermediates”, Chiral Europe ’96 Spring Innovations, 1996, 49-55.

56. N.M. Kelly, R. G. Reid, C.L.Willis and P. L. Winton, Chemo-enzymatic synthesis of isotopically labelled L-valine, L-isoleucine and alloisoleucine. Tetrahedron Letters, 1996, 37, 1517-1520.

55. J.A. O’Neill, S. D. Lindell, T.J. Simpson and C.L.Willis. Enantioselective synthesis of the 13- membered ring macrodiolide, bartanol. J. Chem. Soc., Perkin Trans. 1, 1996, 637-644.

54. A. Sutherland and C. L. Willis, Synthesis of [6-13C]-L-lysine. J. Label. Compd. Radiopharm., 1996, 38, 95-102.

53. N. Broome, P.J. O’Hanlon, T.J. Simpson, R. Stephen and C.L. Willis, Studies on the stereoselectivity of the osmylation of cis-bicyclo[3.3.0]oct-6-enes. J. Chem. Soc., Perkin Trans. 1, 1995, 3067-3072.

52. C.L. Willis and M. Wills, “Organic Synthesis”, Oxford University Press, 1995.

51. Patent, WO 9601, 892 Chiral synthesis of 2-hydroxy acids with Lactobacillus 2-hydroxy carboxylic acid dehydrogenase, K. Johnson, M. Hateley, J. Holbrook and C. L. Willis (1996).
50. N.M. Kelly, R.G. Reid, C.L.Willis and P.L. Winton, Method for the synthesis of L-leucine selectively labeled with carbon-13 or deuterium in either diastereotopic methyl group. Tetrahedron Lett., 1995, 36, 8315-8318.

49. I.H. Gilbert, M. Ginty, J.A. O’Neill, T.J. Simpson, J. Staunton and C.L. Willis. Synthesis of β-keto and α,β-unsaturated N-acetylcysteamine thioesters, Bioorg. Med. Chem. Lett., 1995, 1587-1590.

48. J.M.Bentley, H.J.Wadsworth and C.L. Willis. Enantioselective synthesis of S- and R- 3-hydroxypyrrolidinones via lactate dehydrogenase catalysed reduction of 4-(Cbz-amino)-2-oxobutanoic acid. J. Chem. Soc., Chem. Commun., 1995, 231-232.

47. J.J. Ross, J.B. Reid, S.M. Swain, O. Hasan, T.L. Wand, P. Hedden, C.L. Willis and A.T. Poole. Genetic regulation of gibberellin deactivation in the garden pea. The Plant Journal, 1995, 7, 513-523.

46. C. L. Willis “Enzymatic methods for the enantioselective synthesis of isotopically labelled amino acids” in “Synthesis and Applications of Isotopes and Isotopically Labelled Compounds”, Ed. J.Allen and R. Voges, Wiley 1995, 591-596.

45. M. Penny, C.L. Willis, P. Gaskin and J.R. Lenton. Identification of gibberellins A91 and A92 from developing wheat grain. Phytochemistry, 1994, 37, 1063-1067.

44. N.M. Kelly, B.C. O’Neill, J. Probert, G. Reid, R. Stephen, T. Wang, C.L.Willis and P. Winton. Chemo-enzymatic synthesis of isotopically labelled L-amino acids. Tetrahedron Letters, 1994, 35, 6533-6536.

43. K. Hanson, J.A. O’Neill, T.J. Simpson and C.L. Willis. Bartanol and bartallol, novel macrodiolides from Cytospora sp. ATCC 20502. J. Chem. Soc., Perkin Trans. 1, 1994, 2493-2497.

42. L.J. Sheriff, M.J. McKay, J.J. Ross, J.B. Reid and C.L. Willis. Decapitation reduces the metabolism of gibberellin A20 to GA1 in Pisum sativum L., decreasing the Le/ le difference Plant Physiology, 1994, 104, 277-280.

41. J. A. O’Neill, T.J. Simpson, C.L. Willis and S.D. Lindell. A simple enantioselective synthesis of γ-valerolactone. Tetrahedron: Asymmetry , 1994, 117-118.

40. P.A. Harrison, L. Murtagh and C.L. Willis. Anomalous reactivity of sodium phenylselenide. J. Chem. Soc,. Perkin Commun., 1993, 3047-3050.

39. M.H. Beale, A. Chen, P.A. Harrison and C.L. Willis. A facile aromatisation of abscisic acid J. Chem. Soc., Perkin Trans. 1, 1993, 3061-3064.

38. M. Penny and C.L. Willis. Displacement of a bridgehead mesylate with lithium dialkykcuprates: preparation of 13-methylgibberellin A4. J. Chem Soc.,. Chem. Commun,. 1993, 1111-1112.

37. J.M. Bentley, D.M. Smith, H.J. Wadsworth and C.L. Willis. Isotopic labelling studies on an unstabilised azomethine ylide. J. Chem Res., 1993, 240-241.

36. M. Penny, C.L. Willis, P. Gaskin and J.R. Lenton. Preparation of gibberellins A79 and A90 and their occurrence in mature wheat grain. Phytochemistry, 1993, 33, 951-956.
35. J.A. O’Neill, T.J. Simpson and C.L.Willis. Biosynthesis of colletodiol and related polyketide macrodiolides in Cytospora sp ATCC 20502: synthesis and metabolism of advanced intermediates. J. Chem. Soc, Chem. Comm., 1993, 738-740.

34. M. Penny, C.L. Willis, A.S. Batsanov and J.A.K. Howard. Novel gibberellin epoxy-alcohols: synthesis and X-ray crystal structure. J. Chem. Soc., Perkin Trans. I, 1993, 541-545.

33. J.R. Ross, C.L. Willis, P. Gaskin and J.B. Reid. Shoot elongation in Lathyrus odoratus L: gibberellin levels in light- and dark-grown tall and dwarf seedlings. Planta, 1992 , 187, 10-13.

32. H.M. Wilks, K.M. Moreton, K.W. Hart, J.L. Gelpi, G.M. Casy, R.B. Sessions, C.L. Willis, A.R. Clarke and J.J. Holbrook. “Opportunity for Chiral Synthesis and Redesigned Lactate Dehydrogenases” in “Harnessing Biotechnology for the 21st Century”, ed. M.R. Ladisch and A. Bose, American Chemical Society, Washington D.C., 1992, 150-154.

31. A. Chen, I.A.F. Velebil and C.L. Willis. Deuterium exchange at C-6 of gibberellin 7-methyl esters: anchimeric assistance by the 19,10γ-lactone. Tetrahedron Lett., 1992, 33, 4057-4060.

30. J.R. Hanson and C.L. Willis. The effect of some ent-kaur-16-ene alcohols on gibberellic acid biosynthesis in Gibberella fujikuroi. Phytochemistry, 1992, 31, 2709-2712.

29. P. Gaskin, J. MacMillan I.K. Makinson and C.L. Willis. Preparation of ent-gibberellane and 16-epi-gibberellane J. Chem. Soc., Perkin Trans. I, 1992, 1359-1364.

28. A. Chen, J. MacMillan and C.L. Willis. Partial synthesis of 20-norgibberellin A12 and structural elucidation of a metabolite detected in oilseed rape, Brassica napus. J. Chem. Soc., Perkin Trans. I, 1991, 3235-3239.

27. S.J. Castellaro, J. MacMillan and C.L. Willis. Hydrolysis of gibberellin 7-methyl esters: anchimeric assistance by a 15-alcohol. J. Chem. Soc., Perkin Trans. I, 1991, 2999-3003.

26. C.L. Willis. “Isotopic Labelling of the Gibberellins” in “Isotopes in Physical and Biomedical Sciences, Volume 1” ed. J.R. Jones, Elsevier, Amsterdam 1991, 232-283.

25. M.H. Beale, P. Gaskin, J. MacMillan, I.K. Makinson and C.L. Willis. Two efficient syntheses of gibberellin A81 from gibberellin A3. J. Chem. Soc., Perkin Trans. I, 1991, 1191-1195.

24. M.H. Beale and C.L. Willis. “The Gibberellins” in “Methods in Plant Biochemistry, Volume 4 – The Terpenoids”, ed. B.V. Banthorpe and D.V. Charlwood, Academic Press, London 1991, 289-330.

23. K.S. Albone, P. Gaskin, J. MacMillan and C.L. Willis. The biosynthetic origin of gibberellins A3 and A7 in higher plants: metabolic evidence from seeds of Marah macrocarpus and Malus domestica. Plant Physiology, 1990, 94, 132-142.

22. C.L. Willis. Stereoselectivity of osmylation reactions: synthesis of gibberellins A78 and A79. Tetrahedron Lett., 1990, 31, 6437-6440.

21. S.J. Castellaro, J. MacMillan, A. Singh and C.L. Willis. The preparation and occurrence of gibberellins A75 and A76. J. Chem. Soc., Perkin Trans. I, 1990, 145-152.

20. S.J. Castellaro, S.C. Dolan, J. MacMillan and C.L. Willis. Deuterium labelling of ent-kaur-16-en-19-oic acid at carbon-6 and -7. Phytochemistry, 1990, 29, 1823-1831.

19. C.L. Willis, P. Gaskin and J. MacMillan. [1β,2β,3β-3H3]Gibberellin A20: confirmation of structure by 3H-NMR and mass spectrometry. Phytochemistry, 1988, 27, 3970-3971.

18. A.M. Fowles, M.H. Beale, D.N.M. Jones, J. MacMillan and C.L. Willis. 2-Alkylated gibberellins A1 and A4. J. Chem. Soc., Perkin Trans. I, 1988, 1983-1991.

17. M.K. Baynham, J.M. Dickinson, J.R. Hanson, P.B. Hitchcock and C.L. Willis. The conformation of some site specific inhibitors of the ring contraction step in gibberellin plant hormone biosynthesis. J. Chem. Soc., Perkin Trans. I, 1988, 1455-1460.

16. C.L. Willis. A new approach to the synthesis of 2- and 3-hydroxygibberellins. Tetrahedron Lett., 1987, 28, 6705-6708.

15. C.L. Willis. A novel one-step oxidation of terminal epoxides to allylic aldehydes. Tetrahedron Lett., 1987, 27, 2175-2178.

14. K. Albone, J. MacMillan, A.R. Pitt and C.L. Willis. Isotope labelling in ring A of gibberellin A20. Tetrahedron, 1986, 42, 3203-3214.

13. J. MacMillan and C.L. Willis. The partial synthesis of [1β,2β-2H2]GA1, [2β-2H]GA1, and [2α-2H]GA1. J. Chem. Soc., Perkin Trans I, 1986, 309-313.

12. J. MacMillan and C.L. Willis. The synthesis of 1-methyl and 1α,2α-methylene gibberellins. J. Chem. Soc., Perkin Trans. I, 1985, 2177-2184.

11. T.J. Ingram, J.B. Reid, I.C. Murfet, P. Gaskin, C.L. Willis and J. MacMillan. Internode length in Pisum: The Le gene controls the 3β-hydroxylation of GA20 to GA1. Planta, 1984, 160, 455-463.

10. J. MacMillan and C.L. Willis. Stereoselective deuteration at carbon-2 of the gibberellins. J. Chem. Soc., Perkin Trans. I, 1984, 357-361.

9. J. MacMillan and C.L. Willis. NMR assignments of ring A hydrogens in GA4 methyl ester and some derivatives. J. Chem. Soc., Perkin Trans. I, 1984, 351-355.

8. J.R. Hanson, K.P. Parry, J. Triana and C.L. Willis. The inhibition of gibberellin plant hormone biosynthesis by ent-7-norgibberella-5,16-dienes. Phytochemistry, 1983, 22, 97-101.
7. J.R. Bearder, J. MacMillan, B.O. Phinney, J.R. Hanson, D.E.A. Rivett and C.L. Willis. GA13 aldehyde; a proposed intermediate in the fungal biosynthesis of gibberellin A3. Phytochemistry, 1982, 21, 2225-2230.

6. J.R. Hanson, K.P. Parry and C.L. Willis. The inhibition of gibberellin plant hormone biosynthesis by ent-6-oxo-5β(H)-7-norgibberell-16-enes. Phytochemistry, 1982, 21, 1955-1958.

5. J.R. Hanson, K.P. Parry and C.L. Willis. The inhibition of gibberellin plant hormone biosynthesis by ent-6-hydroxy-5β(H)-7-norgibberellenes. Phytochemistry, 1982, 21, 1575-1583.

4. J.R. Hanson, K.P. Parry, J. Triana and C.L. Willis. New biosynthetically patterned inhibitors of gibberellin plant hormone formation. J. Chem. Soc., Chem. Commun., 1982, 192-193.

3. J.R. Hanson, C.L. Willis and K.P. Parry. The preparation of some ent-7-nor-5(H)-gibberellin biosynthesis inhibitors. J. Chem. Soc., Perkin Trans I, 1981, 3020-3024.

2. J.R. Hanson, K.P. Parry and C.L. Willis. Mimics of intermediates in gibberellin biosynthesis as plant growth regulators. J. Chem. Soc., Chem. Commun., 1981, 285-286.

1. J.R. Hanson, C.L. Willis and K.P. Parry. The inhibition of gibberellin acid biosynthesis by ent-kauran-16β,17-epoxide. Phytochemistry, 1980, 19, 2323-2325.