Natural products isolated from bacteria, fungi and plants from both marine and terrestrial environments are a rich source of compounds of medicinal and agrochemical importance. Our research centres upon:-
- Structure elucidation and total synthesis of natural products
- Development of new synthetic methodology
- Elucidation and exploitation of biosynthetic pathways
- Isotopic labelling and biotransformations
Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics
S-S. Gao, L. Wang, Z. Song, J. Hothersall, E.R. Stevens, J. Connolly, P.J. Winn, R.J. Cox, M. P. Crump, P.R. Race, C.M. Thomas, T.J. Simpson, C.L. Willis, Angew. Chem. Int. Ed., 2017, 56, doi: 10.1002/anie.201611590
This work has been designated a Very Important Paper by Angewandte Chemie, and highlighted on the cover.