Natural products isolated from bacteria, fungi and plants from both marine and terrestrial environments are a rich source of compounds of medicinal and agrochemical importance. Our research centres upon:
♦ Structure elucidation and total synthesis of natural products
♦ Development of new synthetic methodology
♦ Elucidation and exploitation of biosynthetic pathways
♦ Isotopic labelling and biotransformations.
Mixing and Matching Genes of Marine and Terrestrial Origin in the Biosynthesis of the Mupirocin Antibiotics
Where the sea meets the land: The mupirocin biosynthetic gene cluster (BGC) from the terrestrial bacterium Pseudomonas fluorescens was repurposed via a plug-and-play approach with heterologous genes from the marine strain that produces thiomarinol. L. Wang, Z. Song, P.R. Race, J. Spencer, T.J. Simpson, M.P. Crump, C.L. Willis, Chem. Sci., 2020, ASAP, DOI: 10.1039/c9sc06192d