Willis Research Group

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Research Interests


Natural products isolated from bacteria, fungi and plants from both marine and terrestrial environments are a rich source of compounds of medicinal and agrochemical importance. Our research centres upon:-

    • Structure elucidation and total synthesis of natural products
    • Development of new synthetic methodology
    • Elucidation and exploitation of biosynthetic pathways
    • Isotopic labelling and biotransformations

Recent Publication


Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics

ACIE Cover

S-S. Gao, L. Wang, Z. Song, J. Hothersall, E.R. Stevens, J. Connolly, P.J. Winn, R.J. Cox, M. P. Crump, P.R. Race, C.M. Thomas, T.J. Simpson, C.L. Willis, Angew. Chem. Int. Ed., 2017, 56, doi: 10.1002/anie.201611590

This work has been designated a Very Important Paper by Angewandte Chemie, and highlighted on the cover.